SEMG2

Across TCGA cell cohorts, SEMG2 RNA expression is significantly associated with the mutation status of many other genes, with 84 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMG2-associated genes across cancer lineages are CNGB3, PCNX4, and ZNF236. Each is linked with SEMG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMG2-to-partner and partner-to-SEMG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNGB3 grouped by SEMG2-low versus SEMG2-high in BLOOD_Myeloma.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMG2→partner) and Y-score (partner→SEMG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CNGB3 →	+4.807	+0.023	.006	<.001	3	2
LUNG_SCLC	PCNX4 →	+4.269	+0.031	.005	.002	3	2
LUNG_NSCLC_LUAD	ZNF236 →	+2.896	+0.120	.008	<.001	3	2
LARGE_INTESTINE	COL20A1 →	+2.041	+0.362	.007	.001	3	2
BLOOD_Myeloma	ANGPT1 →	+4.807	+0.023	.006	<.001	3	1
BLOOD_Myeloma	PALB2 →	+4.807	+0.023	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

CNGB3 by SEMG2 expression — BLOOD_Myeloma

Explore this box plot interactively →