SEMG2

Across TCGA cell cohorts, SEMG2 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SEMG2-associated genes across cancer lineages are OR1L1, CLEC10A, and NXPH2. Each is linked with SEMG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMG2-to-partner and partner-to-SEMG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L1 grouped by SEMG2-low versus SEMG2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMG2→partner) and Y-score (partner→SEMG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR1L1 →	+0.045	+5.029	<.001	.006	3	2
SKIN	CLEC10A →	+0.022	+2.688	<.001	.008	3	1
SKIN	NXPH2 →	+0.768	+2.874	.003	.005	3	1
SKIN	GLRA4 →	+0.025	+2.882	<.001	.005	3	1
SKIN	OR2F1 →	+0.004	+3.099	<.001	.002	3	1
SKIN	METTL24 →	+0.256	+2.657	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR1L1 by SEMG2 expression — LUNG_SCLC

Explore this box plot interactively →