SEMA7A

Across TCGA patient cohorts, SEMA7A protein abundance is significantly associated with the RNA expression of many other genes, with 11,676 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SEMA7A-associated genes across cancer lineages are PLAUR, TNFAIP6, and ARHGAP22. Each is linked with SEMA7A in more than 3 cancer types. Because this analysis shows association rather than direction, both SEMA7A-to-partner and partner-to-SEMA7A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEMA7A versus PLAUR in BRCA, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA7A→partner) and Y-score (partner→SEMA7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLAUR →	+1.071	+0.540	<.001	.001	3	4
BRCA	TNFAIP6 →	+0.859	+0.532	.008	.002	3	4
GBM	ARHGAP22 →	+0.608	+0.431	<.001	<.001	3	4
HNSC	BEX2 →	-2.343	-0.698	<.001	<.001	3	4
LSCC	LOXL2 →	+1.052	+0.273	<.001	<.001	3	4
LSCC	CTSL →	+0.723	+0.271	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,676 associations by consensus.

SEMA7A vs PLAUR — BRCA

Explore this scatter interactively →