SEMA7A

Across TCGA patient cohorts, SEMA7A mutation is significantly associated with the RNA expression of many other genes, with 1,543 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA7A-associated genes across cancer lineages are RNU2-3P, RN7SL454P, and BUB1P1. Each is linked with SEMA7A in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA7A-to-partner and partner-to-SEMA7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU2-3P grouped by SEMA7A-low versus SEMA7A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA7A→partner) and Y-score (partner→SEMA7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU2-3P →	+0.510	+5.011	<.001	.002	3	3
UCEC	RN7SL454P →	+0.158	+1.920	<.001	.002	3	3
LIHC	BUB1P1 →	+0.066	+5.032	<.001	<.001	3	2
LIHC	IGHVII-40-1 →	+1.099	+4.433	<.001	.002	3	2
LIHC	RN7SL44P →	+0.082	+5.091	<.001	.003	3	2
HNSC	RNU6-1156P →	+0.354	+4.425	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,543 associations by consensus.

RNU2-3P by SEMA7A expression — LUAD

Explore this box plot interactively →