SEMA6D

Across TCGA patient cohorts, SEMA6D RNA expression is significantly associated with the protein abundance of many other proteins, with 18,328 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SEMA6D-associated proteins across cancer lineages are EML1, SARM1, and SEPTIN11. Each is linked with SEMA6D in more than 5 cancer types. Because this analysis shows association rather than direction, both SEMA6D-to-partner and partner-to-SEMA6D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEMA6D versus EML1 in BRCA, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6D→partner) and Y-score (partner→SEMA6D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EML1 →	+0.403	+0.802	<.001	<.001	3	6
LSCC	SARM1 →	+0.472	+1.570	<.001	.001	3	5
BRCA	SEPTIN11 →	+0.421	+0.959	<.001	.001	3	5
HNSC	SIPA1L2_S1244 →	+0.759	+1.406	<.001	<.001	3	5
LSCC	CRMP1 →	+0.707	+1.219	<.001	<.001	3	5
HNSC	DTX3 →	+0.512	+1.730	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,328 associations by consensus.

SEMA6D vs EML1 — BRCA

Explore this scatter interactively →