SEMA6D

Across TCGA pan-cancer cohorts, SEMA6D RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SEMA6D’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SEMA6D RNA is repressed in tumor relative to normal tissue. In most cancer types SEMA6D is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where SEMA6D tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA6D RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.812	<.001	12	view →
KIRP	Male	All	−2.873	<.001	11	view →
COAD	Female	All	−2.802	<.001	11	view →
HNSC	All	III,IV	+0.944	<.001	10	view →
LUAD	Female	III,IV	−2.493	<.001	9	view →
KICH	Female	II,III,IV	−2.357	<.001	9	view →
THCA	Male	All	−1.348	<.001	8	view →
UCEC	All	II,III,IV	−1.982	<.001	6	view →
BRCA	All	All	−1.557	<.001	6	view →
READ	All	All	−2.412	<.001	5	view →
BLCA	Female	All	−0.531	.034	4	view →
PRAD	All	All	−0.942	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SEMA6D–KIRC

Open the KIRC breakdown →