SEMA6D

Across TCGA patient cohorts, SEMA6D protein abundance is significantly associated with the RNA expression of many other genes, with 5,370 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SEMA6D-associated genes across cancer lineages are EVA1A, TMEM70, and DHX35. Each is linked with SEMA6D in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA6D-to-partner and partner-to-SEMA6D results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEMA6D versus EVA1A in GBM, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6D→partner) and Y-score (partner→SEMA6D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EVA1A →	-1.243	-0.377	<.001	<.001	3	2
GBM	TMEM70 →	-0.445	-0.325	<.001	<.001	3	2
LSCC	DHX35 →	+0.502	+0.714	.003	.007	3	2
LSCC	PTPRS →	+0.820	+0.922	.001	.006	3	2
GBM	TFPI2 →	-1.442	-0.466	<.001	<.001	3	2
LSCC	RAPGEFL1 →	+1.175	+0.998	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,370 associations by consensus.

SEMA6D vs EVA1A — GBM

Explore this scatter interactively →