SEMA6D

Across TCGA patient cohorts, SEMA6D mutation is significantly associated with the RNA expression of many other genes, with 4,353 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA6D-associated genes across cancer lineages are HASPIN, OIP5, and KNSTRN. Each is linked with SEMA6D in more than 5 cancer types. Because this analysis shows association rather than direction, both SEMA6D-to-partner and partner-to-SEMA6D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HASPIN grouped by SEMA6D-low versus SEMA6D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6D→partner) and Y-score (partner→SEMA6D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HASPIN →	+0.614	+1.828	<.001	<.001	3	5
UCEC	OIP5 →	+0.588	+1.640	<.001	<.001	3	5
SKCM	KNSTRN →	+0.688	+2.719	<.001	.003	3	5
STAD	NUSAP1 →	+0.599	+2.713	.002	<.001	3	5
SKCM	CDCA5 →	+0.763	+2.732	.001	.003	2	6
UCEC	RAD51 →	+0.572	+1.629	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,353 associations by consensus.

HASPIN by SEMA6D expression — UCEC

Explore this box plot interactively →