SEMA6D

Across TCGA patient cohorts, SEMA6D mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA6D-associated genes across cancer lineages are ASNS, eIF4E, and ACVRL1. Each is linked with SEMA6D in more than 3 cancer types. Because this analysis shows association rather than direction, both SEMA6D-to-partner and partner-to-SEMA6D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SEMA6D-low versus SEMA6D-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6D→partner) and Y-score (partner→SEMA6D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ASNS →	+0.380	+2.321	.018	.030	3	4
UCEC	eIF4E →	+0.185	+1.662	<.001	<.001	3	3
STAD	ACVRL1 →	-0.190	-3.459	.015	.004	3	3
UCEC	Cyclin-B1 →	+0.456	+1.514	.001	.012	3	3
UCEC	FASN →	+0.208	+1.137	.040	.037	3	3
UCEC	JNK_pT183_Y185 →	-0.135	-2.169	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

ASNS by SEMA6D expression — STAD

Explore this box plot interactively →