SEMA6D

Across TCGA cell cohorts, SEMA6D RNA expression is significantly associated with the go_rna of many other GO terms, with 2,332 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SEMA6D-associated GO terms across cancer lineages are Regulation of cytoplasmic translation, Positive regulation of cation transmembrane transport, and Negative regulation of myoblast fusion. Each is linked with SEMA6D in more than 8 cancer types. Because this analysis shows association rather than direction, both SEMA6D-to-partner and partner-to-SEMA6D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cytoplasmic translation grouped by SEMA6D-low versus SEMA6D-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6D→partner) and Y-score (partner→SEMA6D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of cytoplasmic translation →	+0.090	+1.172	.001	<.001	3	9
LUNG_NSCLC_LUSC	Positive regulation of cation transmembrane transport →	-0.101	-1.205	.001	.009	3	8
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.112	+0.950	.001	.006	3	7
OESOPHAGUS	Cytoplasmic translation →	+0.097	+1.143	<.001	.001	3	7
OESOPHAGUS	Respiratory electron transport chain →	+0.096	+1.134	.001	.001	2	8
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.117	+0.942	.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,332 associations by consensus.

Regulation of cytoplasmic translation by SEMA6D expression — OESOPHAGUS

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