SEMA6D

Across TCGA cell cohorts, SEMA6D mutation is significantly associated with the RNA expression of many other genes, with 119 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA6D-associated genes across cancer lineages are AGTR2, OR52B2, and SGPP2. Each is linked with SEMA6D in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA6D-to-partner and partner-to-SEMA6D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGTR2 grouped by SEMA6D-low versus SEMA6D-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6D→partner) and Y-score (partner→SEMA6D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	AGTR2 →	+0.032	+3.643	<.001	.007	3	2
BLOOD_Lymphoma	OR52B2 →	+0.022	+3.714	.001	.006	3	2
LARGE_INTESTINE	SGPP2 →	+1.262	+3.169	.003	.009	3	2
LARGE_INTESTINE	WDR87 →	+0.012	+2.131	.005	.006	3	2
LARGE_INTESTINE	REG1B →	+1.964	+2.196	<.001	.004	3	2
BLOOD_Leukemia	ACTR6 →	+0.545	+3.351	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 119 associations by consensus.

AGTR2 by SEMA6D expression — CNS

Explore this box plot interactively →