SEMA6B

Across TCGA patient cohorts, SEMA6B mutation is significantly associated with the RNA expression of many other genes, with 4,778 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA6B-associated genes across cancer lineages are DCTN4, BPNT2P, and RN7SL98P. Each is linked with SEMA6B in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA6B-to-partner and partner-to-SEMA6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCTN4 grouped by SEMA6B-low versus SEMA6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6B→partner) and Y-score (partner→SEMA6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DCTN4 →	+0.402	+2.446	.002	.001	3	3
BLCA	BPNT2P →	+0.105	+4.266	<.001	.003	3	3
UCEC	RN7SL98P →	+0.091	+2.342	.003	.002	3	3
SKCM	TRIM51DP →	+0.146	+2.951	.002	.003	3	2
SKCM	DNAJB6P8 →	+0.098	+3.011	<.001	.002	3	2
HNSC	RN7SKP205 →	+0.161	+4.912	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,778 associations by consensus.

DCTN4 by SEMA6B expression — UCEC

Explore this box plot interactively →