SEMA6B

Across TCGA pan-cancer cohorts, SEMA6B RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SEMA6B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SEMA6B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEMA6B is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where SEMA6B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA6B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.709	<.001	12	view →
HNSC	Female	III,IV	+1.743	<.001	11	view →
THCA	Female	III,IV	+1.758	<.001	8	view →
STAD	Male	II,III,IV	+1.368	<.001	7	view →
LIHC	Female	II,III,IV	+1.227	<.001	7	view →
CHOL	All	All	+1.584	.002	3	view →
BRCA	Female	All	−0.304	.018	3	view →
READ	Male	All	+1.933	.024	2	view →
UCEC	All	All	−1.202	.002	2	view →
LUAD	All	IV	−0.870	.024	2	view →
LUSC	All	All	−0.625	.002	2	view →
COAD	Male	III,IV	+0.543	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SEMA6B–KIRC

Open the KIRC breakdown →