SEMA6B

Across TCGA patient cohorts, SEMA6B mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA6B-associated genes across cancer lineages are eEF2, eIF4E, and FoxM1. Each is linked with SEMA6B in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA6B-to-partner and partner-to-SEMA6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by SEMA6B-low versus SEMA6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6B→partner) and Y-score (partner→SEMA6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.398	+3.459	.004	.005	3	3
UCEC	eIF4E →	+0.206	+3.183	.012	.009	3	2
UCEC	FoxM1 →	+0.233	+2.502	.021	.002	3	2
UCEC	mTOR_pS2448 →	-0.168	-2.787	.004	.003	3	2
UCEC	Notch1 →	+0.167	+1.584	.002	.036	3	2
UCEC	ASNS →	+0.306	+2.000	.031	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eEF2 by SEMA6B expression — UCEC

Explore this box plot interactively →