SEMA6B

Across TCGA cell cohorts, SEMA6B mutation is significantly associated with the mutation status of many other genes, with 2,757 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA6B-associated genes across cancer lineages are TNRC6C, LRIT1, and LAMA1. Each is linked with SEMA6B in more than 4 cancer types. Because this analysis shows association rather than direction, both SEMA6B-to-partner and partner-to-SEMA6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNRC6C grouped by SEMA6B-low versus SEMA6B-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6B→partner) and Y-score (partner→SEMA6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TNRC6C →	+3.240	+4.467	.004	.004	1	5
LARGE_INTESTINE	LRIT1 →	+3.392	+3.632	<.001	<.001	1	4
LARGE_INTESTINE	LAMA1 →	+1.527	+2.807	.005	.005	1	4
LARGE_INTESTINE	ESRP1 →	+1.807	+2.584	.005	.005	1	4
CNS	JAK3 →	+4.277	+4.584	.001	.001	1	4
BLOOD_Leukemia	ZC3H13 →	+2.870	+3.347	.009	.009	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,757 associations by consensus.

TNRC6C by SEMA6B expression — OVARY

Explore this box plot interactively →