SEMA6B

Across TCGA cell cohorts, SEMA6B mutation is significantly associated with the drug of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA6B-associated genes across cancer lineages are CP724714, Methotrexate, and Nutlin-3a (-). Each is linked with SEMA6B in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA6B-to-partner and partner-to-SEMA6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CP724714 grouped by SEMA6B-low versus SEMA6B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6B→partner) and Y-score (partner→SEMA6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CP724714 →	+0.346	+2.874	.030	.021	3	3
LARGE_INTESTINE	Methotrexate →	+1.008	+2.807	.010	.035	3	1
LARGE_INTESTINE	Nutlin-3a (-) →	+0.792	+3.061	.016	.010	3	1
LARGE_INTESTINE	GSK1904529A →	+0.475	+2.900	.001	.015	3	1
LARGE_INTESTINE	Cyclophosphamide →	+0.340	+2.871	.021	.021	3	1
LARGE_INTESTINE	CP466722 →	+0.392	+2.874	.037	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

CP724714 by SEMA6B expression — LARGE_INTESTINE

Explore this box plot interactively →