SEMA6A

Across TCGA cell cohorts, SEMA6A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,990 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SEMA6A-associated GO terms across cancer lineages are Positive regulation of monoatomic ion transmembrane transport, Regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Regulation of plasminogen activation. Each is linked with SEMA6A in more than 10 cancer types. Because this analysis shows association rather than direction, both SEMA6A-to-partner and partner-to-SEMA6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of monoatomic ion transmembrane transport grouped by SEMA6A-low versus SEMA6A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6A→partner) and Y-score (partner→SEMA6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of monoatomic ion transmembrane transport →	-0.087	-1.137	.009	.002	3	11
SOFT_TISSUE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.143	+1.955	<.001	.002	3	11
LIVER	Regulation of plasminogen activation →	-0.300	-2.183	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA repair →	+0.072	+0.836	<.001	<.001	3	10
SOFT_TISSUE	Regulation of coagulation →	-0.180	-2.352	.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA repair →	+0.067	+0.820	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,990 associations by consensus.

Positive regulation of monoatomic ion transmembrane transport by SEMA6A expression — BONE

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