SEMA6A

Across TCGA cell cohorts, SEMA6A mutation is significantly associated with the RNA expression of many other genes, with 1,427 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA6A-associated genes across cancer lineages are GFRA4, C17orf75, and CRACD. Each is linked with SEMA6A in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA6A-to-partner and partner-to-SEMA6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by SEMA6A-low versus SEMA6A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6A→partner) and Y-score (partner→SEMA6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GFRA4 →	+0.027	+4.662	<.001	.005	3	2
LARGE_INTESTINE	C17orf75 →	+0.441	+2.389	.005	.006	3	2
LARGE_INTESTINE	CRACD →	+0.907	+3.252	.002	.002	3	2
LARGE_INTESTINE	SCD5 →	+1.339	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	CEP78 →	+0.722	+3.321	<.001	.002	3	2
LARGE_INTESTINE	FRA10AC1 →	+0.634	+3.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,427 associations by consensus.

GFRA4 by SEMA6A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →