SEMA6A

Across TCGA cell cohorts, SEMA6A mutation is significantly associated with the mutation status of many other genes, with 6,665 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA6A-associated genes across cancer lineages are SLC4A3, POLR1A, and KIF21A. Each is linked with SEMA6A in more than 5 cancer types. Because this analysis shows association rather than direction, both SEMA6A-to-partner and partner-to-SEMA6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC4A3 grouped by SEMA6A-low versus SEMA6A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA6A→partner) and Y-score (partner→SEMA6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SLC4A3 →	+5.651	+5.651	<.001	<.001	1	6
BREAST	POLR1A →	+4.857	+4.297	.009	.009	1	5
SOFT_TISSUE	KIF21A →	+5.066	+4.502	.007	.007	1	5
SOFT_TISSUE	IGF1R →	+5.066	+4.502	.007	.007	1	5
LARGE_INTESTINE	MYBPC2 →	+2.169	+1.925	.001	.001	1	5
LUNG_SCLC	BIRC6 →	+3.066	+4.369	.005	.005	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,665 associations by consensus.

SLC4A3 by SEMA6A expression — SOFT_TISSUE

Explore this box plot interactively →