SEMA6A-AS2

Across TCGA pan-cancer cohorts, SEMA6A-AS2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SEMA6A-AS2 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SEMA6A-AS2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SEMA6A-AS2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and ESCA show a favorable association.

KIRC, ESCA, and KIRP are the cancer types where SEMA6A-AS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.703	0.548	<.001	111	view →
ESCA	OS	Tertile	All	0.682	0.416	.002	42	view →
KIRP	OS	Quartile	II,III,IV	0.904	0.570	.005	41	view →
THCA	OS	Quartile	III,IV	0.851	0.974	.009	22	view →
PAAD	OS	Median	All	0.521	0.293	.003	18	view →
READ	DFS	Median	II,III,IV	0.902	0.638	.006	13	view →
ACC	DFS	Median	All	0.300	0.709	.012	12	view →
LUAD	DFS	Quartile	IV	0.257	0.799	.014	12	view →
STAD	DFS	Quartile	IV	0.800	0.151	.028	11	view →
MESO	DFS	Tertile	III,IV	0.765	0.272	.025	9	view →
KICH	DFS	Tertile	III,IV	0.245	0.789	.007	8	view →
CHOL	DFS	Tertile	II,III,IV	0.132	0.754	.006	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SEMA6A-AS2–KIRC (OS)

Open the KIRC breakdown →