SEMA6A-AS2

Across TCGA pan-cancer cohorts, SEMA6A-AS2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SEMA6A-AS2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SEMA6A-AS2 RNA is repressed in tumor relative to normal tissue. In most cancer types SEMA6A-AS2 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, KIRC, and THCA are the cancer types where SEMA6A-AS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA6A-AS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.324	<.001	12	view →
KIRC	Female	III,IV	+0.747	<.001	11	view →
THCA	Male	III,IV	−0.594	<.001	11	view →
LUAD	Female	III,IV	−0.706	<.001	7	view →
KICH	All	II,III,IV	−0.402	<.001	7	view →
BRCA	Female	All	−0.413	<.001	6	view →
READ	Female	All	−1.152	<.001	5	view →
KIRP	All	IV	+0.402	.020	5	view →
UCEC	All	IV	−0.880	.002	2	view →
CHOL	All	All	+0.695	<.001	2	view →
LUSC	All	III,IV	−0.243	.023	2	view →
PRAD	All	All	+0.128	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SEMA6A-AS2–COAD

Open the COAD breakdown →