SEMA6A-AS1

Across TCGA pan-cancer cohorts, SEMA6A-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SEMA6A-AS1 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SEMA6A-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SEMA6A-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and THYM show a favorable association.

LIHC, BRCA, and KICH are the cancer types where SEMA6A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.615	0.786	<.001	60	view →
BRCA	OS	Tertile	III,IV	0.961	0.829	.001	52	view →
KICH	DFS	Tertile	III,IV	0.239	1.000	.005	45	view →
SKCM	DFS	Median	II,III,IV	0.466	0.692	<.001	42	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.349	.004	32	view →
OV	DFS	Median	All	0.487	0.590	.003	32	view →
LGG	DFS	Tertile	All	0.784	0.896	<.001	25	view →
ACC	OS	Median	All	1.000	0.392	<.001	25	view →
UCS	DFS	Tertile	IV	0.956	0.510	.024	20	view →
BLCA	OS	Tertile	II,III,IV	0.565	0.366	.023	19	view →
HNSC	OS	Median	III,IV	0.461	0.288	.015	17	view →
UCEC	DFS	Median	II,III,IV	0.774	0.860	.020	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SEMA6A-AS1–LIHC (OS)

Open the LIHC breakdown →