SEMA6A-AS1

Across TCGA pan-cancer cohorts, SEMA6A-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SEMA6A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SEMA6A-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SEMA6A-AS1 is over-expressed in tumor, although a few such as COAD and BRCA show the opposite, repressed pattern.

KIRC, COAD, and BRCA are the cancer types where SEMA6A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA6A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.793	<.001	11	view →
COAD	Female	All	−0.414	<.001	9	view →
BRCA	All	III,IV	−0.563	<.001	6	view →
LUAD	Female	II,III,IV	−0.482	.007	5	view →
KICH	All	All	−0.291	<.001	4	view →
LUSC	All	All	−0.274	<.001	4	view →
THCA	All	All	−0.170	.005	3	view →
CHOL	All	All	+1.230	<.001	2	view →
KIRP	All	IV	+0.442	.009	2	view →
PRAD	All	All	+0.167	.029	2	view →
LIHC	All	All	+0.107	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SEMA6A-AS1–KIRC

Open the KIRC breakdown →