SEMA5B

Across TCGA pan-cancer cohorts, SEMA5B mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of SEMA5B’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SEMA5B mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SEMA5B is over-expressed in tumor.

CCRCC and LUAD are the cancer types where SEMA5B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA5B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+2.216	<.001	12	view →
LUAD	All	II,III,IV	+0.788	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

SEMA5B–CCRCC

Open the CCRCC breakdown →