SEMA5B

Across TCGA pan-cancer cohorts, SEMA5B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SEMA5B data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SEMA5B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SEMA5B expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

UVM, KIRC, and LIHC are the cancer types where SEMA5B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.407	0.713	<.001	77	view →
KIRC	OS	Tertile	All	0.754	0.550	<.001	59	view →
LIHC	DFS	Quartile	All	0.338	0.521	.002	49	view →
THCA	DFS	Quartile	III,IV	0.796	0.962	.001	35	view →
CESC	DFS	Quartile	All	0.357	0.700	.001	30	view →
STAD	DFS	Median	III,IV	0.195	0.509	.019	29	view →
LUAD	DFS	Tertile	IV	0.208	1.000	.011	25	view →
BRCA	OS	Quartile	II,III,IV	0.873	0.937	.010	20	view →
UCS	OS	Quartile	III,IV	0.739	0.350	.034	18	view →
COAD	DFS	Tertile	All	0.636	0.770	.008	15	view →
READ	OS	Median	III,IV	0.826	1.000	.014	13	view →
SKCM	OS	Quartile	All	0.300	0.439	.009	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SEMA5B–UVM (DFS)

Open the UVM breakdown →