SEMA5B

Across TCGA patient cohorts, SEMA5B mutation is significantly associated with the RNA expression of many other genes, with 5,079 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA5B-associated genes across cancer lineages are CEP85, WDHD1, and MKI67. Each is linked with SEMA5B in more than 5 cancer types. Because this analysis shows association rather than direction, both SEMA5B-to-partner and partner-to-SEMA5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP85 grouped by SEMA5B-low versus SEMA5B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA5B→partner) and Y-score (partner→SEMA5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CEP85 →	+0.632	+4.122	<.001	<.001	3	6
LUAD	WDHD1 →	+0.693	+2.333	.001	.003	3	6
UCEC	MKI67 →	+0.545	+1.882	.002	.001	3	6
LUAD	GTSE1 →	+0.802	+3.824	.001	<.001	3	5
UCEC	DCLRE1B →	+0.504	+2.758	<.001	<.001	3	5
UCEC	KNL1 →	+0.600	+2.042	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,079 associations by consensus.

CEP85 by SEMA5B expression — LUAD

Explore this box plot interactively →