SEMA5B

Across TCGA patient cohorts, SEMA5B mutation is significantly associated with the total protein of many other genes, with 89 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SEMA5B-associated genes across cancer lineages are PCNA, ATM, and S6_pS240_S244. Each is linked with SEMA5B in more than 3 cancer types. Because this analysis shows association rather than direction, both SEMA5B-to-partner and partner-to-SEMA5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SEMA5B-low versus SEMA5B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA5B→partner) and Y-score (partner→SEMA5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.189	+2.087	.007	.005	3	4
UCEC	ATM →	-0.462	-2.794	.001	.002	3	4
LUAD	S6_pS240_S244 →	-0.542	-3.321	.031	.010	3	3
SKCM	4E-BP1 →	+0.316	+2.201	.001	<.001	3	3
UCEC	eIF4E →	+0.199	+2.502	.003	.001	3	3
COAD	EGFR_pY1068 →	-0.293	-2.459	.006	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

PCNA by SEMA5B expression — UCEC

Explore this box plot interactively →