SEMA5B

Across TCGA cell cohorts, SEMA5B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,627 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SEMA5B-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Negative regulation of myoblast fusion, and Hippocampus development. Each is linked with SEMA5B in more than 8 cancer types. Because this analysis shows association rather than direction, both SEMA5B-to-partner and partner-to-SEMA5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by SEMA5B-low versus SEMA5B-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA5B→partner) and Y-score (partner→SEMA5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of syncytium formation by plasma membrane fusion →	+0.073	+1.280	.008	.006	2	9
LUNG_SCLC	Negative regulation of myoblast fusion →	+0.072	+1.327	.009	.004	2	8
LUNG_SCLC	Hippocampus development →	+0.069	+1.441	<.001	.001	3	7
OVARY	Regulation of protein folding →	+0.090	+1.120	.002	.009	3	6
LUNG_SCLC	RNA export from nucleus →	+0.098	+1.621	<.001	<.001	3	6
BONE	C-terminal protein lipidation →	-0.231	-3.398	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,627 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by SEMA5B expression — LUNG_SCLC

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