SEMA5B

Across TCGA cell cohorts, SEMA5B mutation is significantly associated with the RNA expression of many other genes, with 345 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA5B-associated genes across cancer lineages are KRT71, LARP1B, and SCD5. Each is linked with SEMA5B in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA5B-to-partner and partner-to-SEMA5B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT71 grouped by SEMA5B-low versus SEMA5B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA5B→partner) and Y-score (partner→SEMA5B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRT71 →	+0.022	+2.922	<.001	.009	3	2
LARGE_INTESTINE	LARP1B →	+0.657	+2.502	.002	.005	3	2
LARGE_INTESTINE	SCD5 →	+1.114	+2.502	.009	.005	3	2
LARGE_INTESTINE	RAB28 →	+0.506	+3.237	.004	.003	3	2
LARGE_INTESTINE	STX5 →	+0.606	+3.389	.001	.001	3	2
LARGE_INTESTINE	USP1 →	+0.533	+3.169	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 345 associations by consensus.

KRT71 by SEMA5B expression — BLOOD_Leukemia

Explore this box plot interactively →