SEMA5A

Across TCGA pan-cancer cohorts, SEMA5A Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SEMA5A data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SEMA5A Mutation is associated with better overall survival. In most high-consensus cancer types, elevated SEMA5A expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, LUSC, and SCLC are the cancer types where SEMA5A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.981	0.860	.008	20	view →
LUSC	OS	Median	IV	0.001	0.673	.014	12	view →
SCLC	OS	Median	All	0.301	0.711	.018	9	view →
LIHC	OS	Median	II,III,IV	0.248	0.715	.042	3	view →
SKCM	DFS	Median	III,IV	0.913	0.569	.021	3	view →
COAD	DFS	Median	III,IV	1.000	0.385	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SEMA5A–UCEC (OS)

Open the UCEC breakdown →