SEMA5A

Across TCGA pan-cancer cohorts, SEMA5A RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SEMA5A’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SEMA5A RNA is repressed in tumor relative to normal tissue. In most cancer types SEMA5A is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LUAD, KICH, and COAD are the cancer types where SEMA5A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA5A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	III,IV	−2.461	<.001	9	view →
KICH	Female	All	−2.231	<.001	7	view →
COAD	Female	II,III,IV	−1.315	<.001	7	view →
LUSC	Female	All	−2.157	<.001	6	view →
BRCA	Female	All	−1.137	<.001	6	view →
STAD	All	II,III,IV	+0.853	.009	3	view →
PRAD	All	All	−0.795	<.001	2	view →
CHOL	All	All	+0.602	.022	2	view →
KIRC	Male	All	−0.540	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SEMA5A–LUAD

Open the LUAD breakdown →