SEMA5A

Across TCGA patient cohorts, SEMA5A protein abundance is significantly associated with the RNA expression of many other genes, with 4,655 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SEMA5A-associated genes across cancer lineages are MIR4636, ENPP2, and JAM3. Each is linked with SEMA5A in more than 3 cancer types. Because this analysis shows association rather than direction, both SEMA5A-to-partner and partner-to-SEMA5A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEMA5A versus MIR4636 in GBM, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA5A→partner) and Y-score (partner→SEMA5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MIR4636 →	+1.246	+0.544	<.001	<.001	3	4
CCRCC	ENPP2 →	+1.071	+0.494	<.001	.004	3	3
GBM	JAM3 →	+0.496	+0.592	<.001	<.001	3	3
BRCA	SNHG18 →	+1.275	+0.796	<.001	.003	3	3
LSCC	SEMA5A-AS1 →	+1.223	+0.994	<.001	<.001	3	3
GBM	MAPK1 →	+0.413	+0.685	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,655 associations by consensus.

SEMA5A vs MIR4636 — GBM

Explore this scatter interactively →