SEMA5A

Across TCGA patient cohorts, SEMA5A mutation is significantly associated with the RNA expression of many other genes, with 5,337 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA5A-associated genes across cancer lineages are MRPL19, CDCA2, and FOXM1. Each is linked with SEMA5A in more than 4 cancer types. Because this analysis shows association rather than direction, both SEMA5A-to-partner and partner-to-SEMA5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL19 grouped by SEMA5A-low versus SEMA5A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA5A→partner) and Y-score (partner→SEMA5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MRPL19 →	+0.434	+3.606	.008	.001	3	5
UCEC	CDCA2 →	+0.680	+1.807	<.001	<.001	3	5
UCEC	FOXM1 →	+0.603	+1.480	.001	<.001	3	5
UCEC	PKN3 →	+0.598	+1.818	<.001	<.001	3	4
UCEC	FRZB →	-0.692	-1.437	.003	.001	3	4
UCEC	MELK →	+0.587	+2.595	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,337 associations by consensus.

MRPL19 by SEMA5A expression — BLCA

Explore this box plot interactively →