SEMA5A

Across TCGA patient cohorts, SEMA5A mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA5A-associated genes across cancer lineages are Caspase-7-cleavedD198, Smad4, and ATM. Each is linked with SEMA5A in more than 4 cancer types. Because this analysis shows association rather than direction, both SEMA5A-to-partner and partner-to-SEMA5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SEMA5A-low versus SEMA5A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA5A→partner) and Y-score (partner→SEMA5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.652	+2.019	<.001	.001	3	5
HNSC	Smad4 →	+0.207	+3.169	.022	.018	3	4
UCEC	ATM →	-0.487	-1.637	<.001	.001	3	4
UCEC	Rad50 →	-0.197	-1.432	.005	.005	3	3
UCEC	Cyclin-B1 →	+0.522	+2.584	.001	.001	3	3
COAD	GAPDH →	+0.565	+3.000	.007	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Caspase-7-cleavedD198 by SEMA5A expression — UCEC

Explore this box plot interactively →