SEMA5A

Across TCGA cell cohorts, SEMA5A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,067 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SEMA5A-associated GO terms across cancer lineages are Negative regulation of actin filament depolymerization, Wound healing, and Negative regulation of amino acid biosynthetic process. Each is linked with SEMA5A in more than 7 cancer types. Because this analysis shows association rather than direction, both SEMA5A-to-partner and partner-to-SEMA5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of actin filament depolymerization grouped by SEMA5A-low versus SEMA5A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA5A→partner) and Y-score (partner→SEMA5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of actin filament depolymerization →	+0.178	+1.670	<.001	<.001	3	8
BONE	Wound healing →	+0.131	+1.766	<.001	<.001	3	8
BONE	Negative regulation of amino acid biosynthetic process →	+0.306	+2.080	.002	.003	3	8
BONE	Negative regulation of amino acid metabolic process →	+0.306	+2.080	.002	.003	3	8
BONE	Substrate adhesion-dependent cell spreading →	+0.226	+1.896	<.001	<.001	3	8
BONE	Positive regulation of proteolysis →	+0.116	+1.838	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,067 associations by consensus.

Negative regulation of actin filament depolymerization by SEMA5A expression — BONE

Explore this box plot interactively →