SEMA5A

Across TCGA cell cohorts, SEMA5A mutation is significantly associated with the RNA expression of many other genes, with 734 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA5A-associated genes across cancer lineages are GOLGA6L1, H2BC1, and KRTAP6-1. Each is linked with SEMA5A in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA5A-to-partner and partner-to-SEMA5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOLGA6L1 grouped by SEMA5A-low versus SEMA5A-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA5A→partner) and Y-score (partner→SEMA5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GOLGA6L1 →	+0.036	+5.169	<.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	H2BC1 →	+0.032	+4.357	<.001	.006	3	2
LUNG_SCLC	KRTAP6-1 →	+0.042	+4.058	<.001	.007	3	2
OVARY	OR52A1 →	+0.007	+3.405	<.001	.005	3	2
LARGE_INTESTINE	SNRPD3 →	+0.450	+2.628	.004	.002	3	2
LARGE_INTESTINE	SLC25A19 →	+0.504	+3.082	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 734 associations by consensus.

GOLGA6L1 by SEMA5A expression — BONE

Explore this box plot interactively →