SEMA5A-AS1

Across TCGA pan-cancer cohorts, SEMA5A-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SEMA5A-AS1 data layer.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher SEMA5A-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SEMA5A-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and KIRC show a favorable association.

UCS, KIRC, and ESCA are the cancer types where SEMA5A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	DFS	Tertile	II,III,IV	0.705	0.192	<.001	82	view →
KIRC	DFS	Tertile	All	0.730	0.557	.001	60	view →
ESCA	OS	Quartile	III,IV	0.594	0.323	.017	32	view →
MESO	OS	Tertile	All	0.522	0.310	.008	29	view →
PAAD	OS	Median	II,III,IV	0.288	0.531	.013	27	view →
CESC	DFS	Tertile	All	0.846	0.690	.002	20	view →
BLCA	DFS	Tertile	IV	0.731	0.335	.010	15	view →
UVM	DFS	Tertile	All	0.443	0.634	.036	12	view →
BRCA	OS	Tertile	III,IV	0.968	0.873	.022	12	view →
COAD	OS	Median	II,III,IV	0.900	0.793	.019	10	view →
THYM	OS	Tertile	All	0.877	0.982	.038	6	view →
SARC	DFS	Median	All	0.479	0.662	.013	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SEMA5A-AS1–UCS (DFS)

Open the UCS breakdown →