SEMA5A-AS1

Across TCGA pan-cancer cohorts, SEMA5A-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of SEMA5A-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SEMA5A-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SEMA5A-AS1 is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

HNSC, KICH, and BRCA are the cancer types where SEMA5A-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA5A-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−0.036	.005	5	view →
KICH	All	II,III,IV	−0.122	.009	3	view →
BRCA	All	III,IV	−0.084	<.001	2	view →
PAAD	Male	All	+0.075	.037	2	view →
KIRC	Male	All	−0.022	.023	2	view →
READ	Female	All	+0.144	.006	1	view →
THCA	Male	II,III,IV	+0.021	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

SEMA5A-AS1–HNSC

Open the HNSC breakdown →