SEMA4G

Across TCGA patient cohorts, SEMA4G protein abundance is significantly associated with the RNA expression of many other genes, with 14,360 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SEMA4G-associated genes across cancer lineages are VCPKMT, TIMM9, and SNW1. Each is linked with SEMA4G in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA4G-to-partner and partner-to-SEMA4G results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEMA4G versus VCPKMT in PDAC, with a Pearson correlation of -0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4G→partner) and Y-score (partner→SEMA4G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	VCPKMT →	-0.603	-0.927	<.001	.001	3	1
PDAC	TIMM9 →	-0.574	-1.358	.001	<.001	3	1
PDAC	SNW1 →	-0.684	-1.271	.003	.001	3	1
PDAC	MTHFD1 →	-0.755	-1.228	.008	.004	3	1
PDAC	PSMC1 →	-0.605	-0.838	.002	.004	3	1
PDAC	PPP4R3A →	-0.432	-0.809	.004	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,360 associations by consensus.

SEMA4G vs VCPKMT — PDAC

Explore this scatter interactively →