SEMA4G

Across TCGA patient cohorts, SEMA4G mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA4G-associated genes across cancer lineages are ASNS, ERK2, and JNK_pT183_Y185. Each is linked with SEMA4G in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA4G-to-partner and partner-to-SEMA4G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by SEMA4G-low versus SEMA4G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4G→partner) and Y-score (partner→SEMA4G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.540	+2.459	<.001	.019	3	3
UCEC	ERK2 →	+0.174	+2.000	.045	.032	3	2
UCEC	JNK_pT183_Y185 →	-0.231	-3.169	.002	.018	3	2
UCEC	p62 Lck ligand →	+0.365	+3.009	.012	.019	3	2
UCEC	Smad3 →	+0.135	+2.459	.046	.019	3	2
UCEC	Cyclin-E2 →	+0.161	+2.000	.034	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

ASNS by SEMA4G expression — UCEC

Explore this box plot interactively →