SEMA4G

Across TCGA cell cohorts, SEMA4G RNA expression is significantly associated with the go_rna of many other GO terms, with 5,395 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SEMA4G-associated GO terms across cancer lineages are Fatty acid beta-oxidation, Base-excision repair, gap-filling, and Viral translational termination-reinitiation. Each is linked with SEMA4G in more than 12 cancer types. Because this analysis shows association rather than direction, both SEMA4G-to-partner and partner-to-SEMA4G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fatty acid beta-oxidation grouped by SEMA4G-low versus SEMA4G-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4G→partner) and Y-score (partner→SEMA4G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Fatty acid beta-oxidation →	+0.087	+1.905	<.001	<.001	3	13
BONE	Base-excision repair, gap-filling →	+0.116	+1.389	<.001	<.001	3	12
BLOOD_Lymphoma	Viral translational termination-reinitiation →	+0.075	+0.678	<.001	<.001	3	12
LARGE_INTESTINE	Copper ion export →	-0.187	-2.171	<.001	<.001	3	12
BREAST	Positive regulation of ceramide biosynthetic process →	+0.144	+1.571	<.001	<.001	3	11
BREAST	Positive regulation of sphingolipid biosynthetic process →	+0.144	+1.571	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,395 associations by consensus.

Fatty acid beta-oxidation by SEMA4G expression — LARGE_INTESTINE

Explore this box plot interactively →