SEMA4G

Across TCGA cell cohorts, SEMA4G mutation is significantly associated with the RNA expression of many other genes, with 144 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA4G-associated genes across cancer lineages are GAGE12G, OR2M4, and CCDC60. Each is linked with SEMA4G in more than 1 cancer types. Because this analysis shows association rather than direction, both SEMA4G-to-partner and partner-to-SEMA4G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12G grouped by SEMA4G-low versus SEMA4G-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4G→partner) and Y-score (partner→SEMA4G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GAGE12G →	+0.340	+4.977	<.001	.007	3	1
OVARY	OR2M4 →	+0.060	+3.700	<.001	.005	3	1
OVARY	CCDC60 →	+0.059	+4.643	<.001	<.001	3	1
OVARY	NLRP2B →	+0.048	+4.392	.002	.004	3	1
LARGE_INTESTINE	DEPDC5 →	+0.501	+3.584	.003	<.001	3	1
LARGE_INTESTINE	ZMYND8 →	-0.630	-2.179	.005	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

GAGE12G by SEMA4G expression — SKIN

Explore this box plot interactively →