SEMA4F

Across TCGA pan-cancer cohorts, SEMA4F Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SEMA4F data layer compared with 26 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SEMA4F Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SEMA4F expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, HNSC, and SARC are the cancer types where SEMA4F Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.295	0.700	.006	12	view →
HNSC	DFS	Median	IV	0.122	0.670	.008	9	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
PRAD	DFS	Median	All	0.152	0.774	.004	6	view →
BLCA	OS	Median	IV	0.130	0.599	.002	6	view →
READ	OS	Median	II,III,IV	0.187	0.653	.030	3	view →
UCEC	DFS	Median	All	0.914	0.625	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SEMA4F–LUAD (OS)

Open the LUAD breakdown →