Across TCGA cell cohorts, SEMA4D mutation is significantly associated with the mutation status of many other genes, with 3,933 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SEMA4D-associated genes across cancer lineages are PCDHGC5, DMD, and LAMA5. Each is linked with SEMA4D in more than 3 cancer types. Because this analysis shows association rather than direction, both SEMA4D-to-partner and partner-to-SEMA4D results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4D→partner) and Y-score (partner→SEMA4D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PCDHGC5 →	+4.145	+4.635	.001	.001	1	4
URINARY_TRACT	DMD →	+3.672	+4.307	.004	.004	1	3
URINARY_TRACT	LAMA5 →	+3.087	+4.000	.008	.008	1	3
SKIN	SLC22A14 →	+3.532	+3.736	<.001	<.001	1	3
SKIN	KIT →	+3.117	+3.117	.009	.009	1	3
SKIN	SYNPO2 →	+3.117	+3.117	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,933 associations by consensus.

Exploration

SEMA4D survival (RNA) · tumor vs normal (RNA) · all SEMA4D data types