SEMA4C

Across TCGA pan-cancer cohorts, SEMA4C mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SEMA4C data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SEMA4C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SEMA4C expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where SEMA4C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.850	0.598	.002	18	view →
CCRCC	OS	Quartile	III,IV	0.389	0.982	.004	9	view →
PDAC	DFS	Quartile	II,III,IV	0.269	0.677	.039	2	view →
LUAD	OS	Tertile	III,IV	0.904	0.400	.037	2	view →
LSCC	OS	Median	All	1.000	0.800	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SEMA4C–HNSC (OS)

Open the HNSC breakdown →