SEMA4C

Across TCGA patient cohorts, SEMA4C protein abundance is significantly associated with the RNA expression of many other genes, with 9,717 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SEMA4C-associated genes across cancer lineages are CCDC92, ANKRD39, and DIP2B. Each is linked with SEMA4C in more than 4 cancer types. Because this analysis shows association rather than direction, both SEMA4C-to-partner and partner-to-SEMA4C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SEMA4C versus CCDC92 in UCEC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4C→partner) and Y-score (partner→SEMA4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC92 →	+0.590	+0.460	<.001	.001	3	5
LSCC	ANKRD39 →	+0.278	+0.258	<.001	<.001	3	4
OV	DIP2B →	+0.869	+0.461	<.001	<.001	3	4
UCEC	SLC15A3 →	-0.765	-0.545	.001	<.001	3	4
LSCC	SOX4 →	+1.141	+0.263	<.001	.003	3	4
LSCC	MEX3A →	+1.585	+0.374	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,717 associations by consensus.

SEMA4C vs CCDC92 — UCEC

Explore this scatter interactively →