SEMA4C

Across TCGA patient cohorts, SEMA4C mutation is significantly associated with the RNA expression of many other genes, with 3,212 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SEMA4C-associated genes across cancer lineages are GPRIN1, ELP5, and MRPS11. Each is linked with SEMA4C in more than 2 cancer types. Because this analysis shows association rather than direction, both SEMA4C-to-partner and partner-to-SEMA4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPRIN1 grouped by SEMA4C-low versus SEMA4C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4C→partner) and Y-score (partner→SEMA4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPRIN1 →	+0.550	+3.906	.001	<.001	3	3
UCEC	ELP5 →	+0.287	+1.887	.006	.004	3	3
UCEC	MRPS11 →	+0.327	+2.033	<.001	<.001	3	3
COAD	IFI27L1 →	+0.825	+3.183	<.001	.009	3	3
SKCM	DHRS11 →	+0.658	+3.510	<.001	.002	3	2
UCEC	CCL5 →	+0.885	+2.321	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,212 associations by consensus.

GPRIN1 by SEMA4C expression — UCEC

Explore this box plot interactively →