SEMA4C

Across TCGA cell cohorts, SEMA4C RNA expression is significantly associated with the go_rna of many other GO terms, with 5,334 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SEMA4C-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Heterochromatin organization, and Protein localization to cytoplasmic stress granule. Each is linked with SEMA4C in more than 12 cancer types. Because this analysis shows association rather than direction, both SEMA4C-to-partner and partner-to-SEMA4C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by SEMA4C-low versus SEMA4C-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SEMA4C→partner) and Y-score (partner→SEMA4C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.165	+1.764	<.001	<.001	3	13
STOMACH	Heterochromatin organization →	+0.061	+1.090	<.001	<.001	3	12
BONE	Protein localization to cytoplasmic stress granule →	+0.138	+1.166	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Late viral transcription →	+0.140	+1.488	.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Positive regulation of double-strand break repair →	+0.068	+1.186	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.052	+1.029	.004	.004	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,334 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by SEMA4C expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →