SEMA3F

Across TCGA pan-cancer cohorts, SEMA3F mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SEMA3F data layer compared with 24 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SEMA3F mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SEMA3F expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where SEMA3F mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	0.366	0.897	.004	57	view →
PDAC	DFS	Median	II,III,IV	0.402	0.900	.013	11	view →
HNSC	OS	Quartile	II,III,IV	1.000	0.875	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SEMA3F–LUAD (OS)

Open the LUAD breakdown →