SEMA3F

Across TCGA pan-cancer cohorts, SEMA3F mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SEMA3F’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SEMA3F mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SEMA3F is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, LUAD, and PDAC are the cancer types where SEMA3F tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SEMA3F mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−0.670	<.001	8	view →
LUAD	Male	All	−0.565	<.001	7	view →
PDAC	All	All	+1.588	<.001	5	view →
CCRCC	All	All	+0.281	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SEMA3F–HNSC

Open the HNSC breakdown →